| Interpro Signature | Unipeptide Families |
| (2R)-phospho-3-sulfolactate synthase, ComA | 3945, 10590, 13675 |
| (Uracil-5)-methyltransferase | 8804, 10178 |
| 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase | 4552, 10823 |
| 1-aminocyclopropane-1-carboxylate synthase | 252, 620, 740, 1592, 1697, 14004, 19757 |
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1619, 19931 |
| 11-S plant seed storage protein | 102, 919, 4671, 16153, 18814, 20095 |
| 14-3-3 protein | 10, 3038, 8121, 9442, 19572 |
| 16S rRNA processing protein RimM | 7236 |
| 2 , 3 cyclic phosphodiesterase, plant | 4924 |
| 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase | 263 |
| 2,3-diketo-5-methylthio-1-phosphopentane phosphatase | 8252 |
| 2-nitropropane dioxygenase, NPD | 3163, 12195, 12606, 22014 |
| 2-oxo acid dehydrogenase, lipoyl-binding site | 139, 790, 916, 1092, 3619, 4162, 4318, 15299, 15606, 16576 |
| 2-oxoglutarate dehydrogenase, E1 component | 1208 |
| 2-phosphoglycolate phosphatase, eukaryotic | 1343 |
| 2-S globulin | 2391, 12333 |
| 20S proteasome, A and B subunits | 369, 732, 1102, 1185, 1268, 1282, 1314, 1373, 1581, 1624, 1913, 1921, 2003, 8181, 14986, 15899, 17739 |
| 26S proteasome non-ATPase regulatory subunit Nin1/mts3 | 2005, 17637, 19208 |
| 26S proteasome subunit P45 | 335, 707, 1010, 1026, 1130 |
| 2Fe-2S ferredoxin subdomain | 303 |
| 2Fe-2S ferredoxin, iron-sulfur binding site | 303, 654, 1344, 2202, 6322, 10196, 10710, 17833 |
| 2OG-Fe(II) oxygenase | 104, 163, 201, 218, 281, 1044, 1100, 1381, 1745, 1925, 2199, 2399, 2550, 3185, 4418, 4589, 5231, 5812, 6206, 6654, 7527, 7681, 9485, 11982, 12237, 12485, 12979, 12986, 14556, 16073, 16421, 16450, 16864, 17015, 17935, 18090, 18383, 18760, 19057, 19816, 19847, 19885, 20244, 21684, 22053 |
| 3'-5' exonuclease | 2286, 3457, 4304, 4466, 6597, 7148 |
| 3'-5' exonuclease | 3457, 4304, 5392, 6597, 8214, 9165 |
| 3'5'-cyclic nucleotide phosphodiesterase | 19906 |
| 3(2),5 -bisphosphate nucleotidase HAL2 | 1114 |
| 3,4-Dihydroxy-2-butanone 4-phosphate synthase | 1210 |
| 3-beta hydroxysteroid dehydrogenase/isomerase | 61, 334, 2101, 4126, 21985 |
| 3-dehydroquinate synthase | 5322, 10447 |
| 3-dehydroquinate synthase AroB | 2359 |
| 3-hydroxy-3-methylglutaryl Coenzyme A reductase | 571 |
| 3-hydroxyacyl-CoA dehydrogenase | 350 |
| 3-hydroxyacyl-CoA dehydrogenase, C-terminal | 350, 3375, 20495 |
| 3-hydroxyacyl-CoA dehydrogenase, NAD-binding | 350, 3375 |
| 3-isopropylmalate dehydratase small subunit | 2821 |
| 3-isopropylmalate dehydrogenase | 1911 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal | 2898, 5369, 5574, 6591, 8534, 9480, 9546, 11198, 12736 |
| 3-oxoacyl-(acyl-carrier-protein) reductase | 1641 |
| 3-phosphoshikimate 1-carboxyvinyltransferase | 1683 |
| 4'-phosphopantetheinyl transferase | 7361, 7664, 18415 |
| 4-diphosphocytidyl-2-methyl-D-erythritol synthase | 4554 |
| 4-diphosphocytidyl-2C-methyl-D-erythritol synthase | 3132, 3863, 4554 |
| 4-hydroxybenzoate polyprenyl transferase, proteobacterial | 6490 |
| 4-hydroxyphenylpyruvate dioxygenase | 1895 |
| 4Fe-4S ferredoxin, iron-sulfur binding | 1344, 1770, 6894, 7583, 8273, 10966, 11862, 12576, 12580 |
| 5'3'-Exonuclease N- and I-domain | 6775, 11702 |
| 5'-3' exonuclease | 3035, 6817, 10478, 19671 |
| 5'3'-Exonuclease N- and I-domain | 3035, 6817, 10478, 13108, 17295, 19671 |
| 5-AMP-activated protein kinase, beta subunit, complex-interacting region | 1559, 5193, 19838, 20983 |
| 5-formyltetrahydrofolate cyclo-ligase | 3692, 8947 |
| 5-methylthioribose kinase | 2164 |
| 6,7-dimethyl-8-ribityllumazine synthase | 2884 |
| 6-phosphofructo-2-kinase | 1833 |
| 6-phosphogluconate dehydrogenase | 463, 1456, 1959, 3735 |
| 6-phosphogluconate dehydrogenase, C-terminal | 463, 14174 |
| 6-phosphogluconate dehydrogenase, C-terminal-like | 320, 350, 463, 631, 793, 1456, 1799, 1959, 3375, 3735, 4406, 5102, 8519, 10825, 11009, 14174, 17639, 18421, 20495 |
| 6-phosphogluconate dehydrogenase, decarboxylating | 463 |
| 6-phosphogluconate dehydrogenase, NAD-binding | 463, 1456, 1959, 3735, 18421 |
| 6-phosphogluconate-binding site | 463 |
| 6-phosphogluconolactonase | 829 |
| 60 kDa inner membrane insertion protein | 1563, 3532, 15225 |
| 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK | 6125 |
| 7,8-dihydro-8-oxoguanine triphosphatase | 21850 |
| 7-Fold repeat in clathrin and VPS proteins | 932, 2757, 3070, 6386, 8223, 9393, 10588, 12661 |
| 8-oxoguanine DNA glycosylase, N-terminal | 6173 |
| A/G-specific adenine glycosylase MutY | 983, 11022 |
| A49-like RNA polymerase I associated factor | 5872, 15812 |
| AAA ATPase | 80, 82, 85, 106, 144, 157, 203, 204, 228, 265, 307, 335, 400, 476, 707, 958, 959, 1010, 1026, 1047, 1090, 1130, 1135, 1407, 1474, 1484, 1605, 1753, 1818, 1958, 1988, 2002, 2209, 2410, 2632, 2653, 3160, 3505, 3519, 3561, 3659, 3883, 4338, 4532, 4817, 5055, 5329, 5390, 6246, 6248, 6602, 6732, 6801, 6804, 9379, 10241, 11227, 11514, 11719, 14072, 17152, 17509 |
| AAA ATPase VAT, N-terminal | 204, 11921, 12632 |
| AAA ATPase, CDC48 | 204 |
| AAA ATPase, central region | 144, 203, 204, 225, 228, 265, 335, 400, 707, 958, 959, 1010, 1026, 1047, 1130, 1407, 1753, 2002, 3160, 3561, 3659, 3883, 4532, 4825, 6248, 8659, 9379, 9695, 10151, 10241, 10484, 10485, 10582, 11227, 11514, 11719, 12331, 13259, 14245, 14256, 15125, 15306, 15547, 17509, 18309, 20894, 20979 |
| AAA-protein subdomain | 144, 204, 228, 265, 335, 400, 707, 959, 1010, 1026, 1130, 1753, 2002, 9379, 10485, 11514, 13259, 14256 |
| AAR2 | 6944, 12510 |
| AARP2CN | 4051, 14804 |
| AB-hydrolase associated lipase region | 1655, 8329 |
| AB-hydrolase YheT, putative | 3175, 3276 |
| ABA/WDS induced protein | 645, 6024, 6452, 7830, 8039, 16948, 18726 |
| ABC transporter related | 82, 85, 106, 126, 206, 307, 396, 476, 652, 1073, 1135, 1163, 1484, 1930, 1958, 2209, 2303, 2646, 2653, 3084, 3312, 3487, 3505, 3519, 3636, 4002, 4817, 4968, 5055, 5390, 5857, 6732, 7136, 7966, 9964, 10416, 10835, 13228, 13511, 14103, 16155, 20032 |
| ABC transporter, ABCE | 20566 |
| ABC transporter, transmembrane region | 82, 85, 3519, 13666, 13681, 17538 |
| ABC transporter, transmembrane region, type 1 | 82, 85, 3519, 4817, 13666, 13681, 13706, 16040, 17538, 18334 |
| ABC-1 | 518, 1194, 1985, 2813, 2976, 4511, 4956, 11814, 16019, 16216 |
| ABC-2 | 106, 476, 1135, 1484, 5278, 5742, 8210, 9716, 11589, 16344, 18338, 19682 |
| Abortive infection protein | 4363, 5111, 5688, 7676, 9870, 12010, 13838, 18746 |
| Acetamidase/Formamidase | 2126, 19106 |
| Acetate--CoA ligase | 1139 |
| Acetohydroxy acid isomeroreductase | 631 |
| Acetohydroxy acid isomeroreductase C-terminal | 631, 17639 |
| Acetohydroxy acid isomeroreductase, catalytic | 631 |
| Acetolactate synthase, small subunit | 1803, 9760, 17446 |
| Acetyl-CoA biotin carboxyl carrier | 2351, 15869 |
| Acetyl-CoA carboxylase carboxyl transferase, beta subunit | 6209 |
| Acetyl-CoA carboxylase, alpha subunit | 4962, 13698 |
| Acetyl-CoA carboxylase, biotin carboxylase | 2650 |
| Acetyl-coenzyme A carboxyltransferase, C-terminal | 1206, 2360, 4962 |
| Acetyl-coenzyme A carboxyltransferase, N-terminal | 1206, 2360, 6209, 9394 |
| Acetylglutamate kinase | 3345 |
| Acid phosphatase (Class B) | 323, 834, 11243, 20130 |
| Acid phosphatase, type 5 | 1278 |
| Acid phosphatase/vanadium-dependent haloperoxidase | 45, 79, 904, 1825, 4259, 5148, 6997, 7190, 8247, 9812, 13033, 13178, 15273, 20294, 21721 |
| Acid phosphatase/vanadium-dependent haloperoxidase related | 1825, 7190, 9812 |
| Acireductone dioxygenase, ARD | 1096 |
| Aconitate hydratase, C-terminal | 274, 2821, 6016 |
| Aconitate hydratase, N-terminal | 15, 274, 1792, 6016, 6521, 15828, 21124 |
| Actin | 9, 10414, 10422, 12557, 14137 |
| Actin-binding FH2 | 589, 1283, 8183, 11076, 20522 |
| Actin-binding WH2 | 10274 |
| Actin-binding, actinin-type | 32, 175, 1342 |
| Actin-binding, cofilin/tropomyosin type | 136, 8625, 20731 |
| Actin-crosslinking proteins | 1594, 2109, 2407, 10005, 10868, 16565, 16764, 16833 |
| Actin/actin-like | 9, 2633, 4107, 4396, 4575, 4840, 6040, 6044, 9173, 9846, 9983, 10288, 10414, 10422, 12557, 13429, 14137, 16967, 17528, 20439, 20610 |
| Acyl carrier protein (ACP) | 565, 870, 11664, 12947, 13608 |
| Acyl carrier protein-like | 565, 870, 1720, 11664, 12947, 13608, 19187, 19574 |
| Acyl-ACP thioesterase | 607, 13181, 18141, 20789 |
| Acyl-CoA dehydrogenase | 300, 1313, 1603, 7417, 20562 |
| Acyl-CoA dehydrogenase C-terminal-like | 1313, 1438, 1603, 2339, 2674, 2926, 8388, 9453, 9541, 20562 |
| Acyl-CoA dehydrogenase, central region | 1313, 1603, 2339, 2674, 2926, 12659 |
| Acyl-CoA dehydrogenase, middle and N-terminal | 1313, 1438, 1603, 2339, 2674, 2926, 12656, 12659, 15671 |
| Acyl-CoA dehydrogenase, N-terminal | 1313, 1603, 12656 |
| Acyl-CoA dehydrogenase, type 1 | 1313, 1603, 2339, 2674, 2926 |
| Acyl-CoA desaturase | 3797 |
| Acyl-CoA oxidase, C-terminal | 1438, 2926, 8388 |
| Acyl-CoA thioesterase | 3166, 10168, 21883 |
| Acyl-coA-binding protein, ACBP | 1504, 3055, 8379, 9423, 10335 |
| Acyl-CoA_oxidase | 2926 |
| Acylneuraminate cytidylyltransferase | 3223, 16999 |
| Acylphosphatase | 5528, 9883 |
| Adaptin, N-terminal | 962, 974, 1046, 1302, 4426, 7139, 12466, 12734, 14569, 14860, 15916, 15938, 17352, 20060, 21799 |
| Adenine nucleotide translocator 1 | 39, 392, 1105, 1420, 1507, 3665, 3817, 5147, 5162, 7502, 12335, 12700 |
| Adenine phosphoribosyl transferase | 728 |
| Adenosine deaminase/editase | 10001, 21789 |
| Adenosine kinase | 705, 13332 |
| Adenosine/AMP deaminase | 1472, 4207, 10928, 13631, 17658 |
| Adenosine/AMP deaminase active site | 733, 1472, 2194, 4591, 6204, 15870, 18648 |
| Adenylate cyclase | 4416, 7853, 8383 |
| Adenylate kinase | 771, 1013, 1239, 2053, 11644, 14231, 19225, 20338, 20881 |
| Adenylate kinase, lid region | 1239 |
| Adenylate kinase, subfamily | 1239, 2053 |
| Adenylate/cytidine kinase, N-terminal | 771, 1239 |
| Adenylosuccinate synthetase | 1389 |
| Adenylyl cyclase class-3/4/guanylyl cyclase | 13337 |
| Adenylylsulfate kinase | 1788 |
| Adhesion regulating molecule | 4372, 9688 |
| ADP-glucose pyrophosphorylase | 316 |
| ADP-ribosylation factor | 12, 289, 462, 572, 1250, 5247, 9529, 11457, 15599, 17934, 19181, 21892 |
| ADP/ATP carrier protein | 1095, 16238 |
| Adrenodoxin | 4183, 19841 |
| Adrenodoxin reductase | 664, 852, 1255, 1756, 3290, 4015, 5497, 9309, 11224, 11441, 13185, 14066 |
| Aerolysin/hemolysin toxin | 10868 |
| AFG1-like ATPase | 3114, 5776, 11980, 14471, 17662, 18744 |
| Agenet | 2617, 5393, 5935, 9081, 11228, 16911 |
| Agglutinin | 4240, 10868, 20959 |
| Agglutinin2 | 10868, 21748 |
| AICARFT/IMPCHase bienzyme | 2146 |
| AIG1 | 1885, 2093, 10602, 13757 |
| AIG2-like | 3014 |
| AIR synthase related protein | 2621 |
| AIR synthase related protein, C-terminal | 1846, 2621, 17025, 17071 |
| Alanine racemase, N-terminal | 1801 |
| Alanine racemase/group IV decarboxylase, C-terminal | 2274, 3515 |
| Alanyl-tRNA synthetase, class IIc | 3300, 5606, 9538 |
| Alba, DNA/RNA-binding protein | 1195, 4887, 10308, 12134, 20561 |
| Albumin I | 4537 |
| Alcohol dehydrogenase GroES-like | 83, 110, 1163, 1183, 1419, 1422, 2031, 2838, 2913, 3141, 3748, 4242, 10653, 14390, 14523, 19020, 19871 |
| Alcohol dehydrogenase superfamily, zinc-containing | 83, 110, 327, 1163, 1183, 1419, 1422, 2031, 2838, 2913, 3141, 3403, 3715, 3748, 4242, 8663, 10399, 10569, 10653, 11280, 11950, 12896, 14390, 14464, 14523, 15410, 16133, 16605, 17965, 18916, 19020, 19753, 19851, 19871, 20511 |
| Alcohol dehydrogenase, zinc-binding | 83, 110, 327, 1163, 1183, 1419, 1422, 2031, 2838, 2913, 3141, 3403, 3748, 4242, 10399, 10569, 11280, 14390, 16133, 17965, 20511 |
| Alcohol dehydrogenase, zinc-containing | 83, 110, 1210, 1422, 4242, 6019, 14523, 15795, 15798, 19871 |
| Alcohol oxidase | 577 |
| Aldehyde dehydrogenase | 21, 26, 28, 54, 118, 314, 339, 532, 722, 1147, 1161, 1324, 1347, 1497, 1572, 1649, 1838, 2098, 3278, 3350, 3497, 3917, 5953, 6063, 7013, 7486, 7491, 7680, 8271, 9738, 10508, 12243, 13169, 13277, 13530, 13823, 14053, 14228, 14736, 15421, 16146, 17830, 18798, 19830, 20548 |
| Aldehyde dehydrogenase NAD(P)-dependent | 532 |
| Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead | 557, 654, 2733 |
| Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding | 654, 2390, 16984 |
| Aldo/keto reductase | 13, 32, 126, 233, 562, 743, 960, 1537, 1562, 2041, 2097, 3000, 3026, 3471, 4193, 5014, 5304, 7963, 8073, 10043, 10574, 12249, 15616, 16192, 17195, 18930, 19520, 19827, 20303, 20887 |
| Aldose 1-epimerase | 489, 559, 2819, 13094, 17519 |
| ALG3 | 5416, 10963, 11942 |
| ALG6, ALG8 glycosyltransferase | 4408, 9706, 10202 |
| Alg9-like mannosyltransferase | 2901, 6824, 9636, 10031, 12132 |
| Alkaline phosphatase | 3136, 11670 |
| Alkaline phytoceramidase | 1527, 2498, 4785, 5311, 17127 |
| Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen | 558, 1202, 3808, 19846 |
| Allene oxide cyclase | 2013, 19226, 20515 |
| Allergen V5/Tpx-1 related | 15, 189, 14328 |
| Allinase, C-terminal | 1062 |
| Alpha 1,4-glycosyltransferase conserved region | 139, 7202, 10150 |
| Alpha amylase, catalytic region | 399, 750, 1494, 4515, 11188, 16285, 20940 |
| Alpha amylase, catalytic subdomain | 750 |
| Alpha tubulin | 0, 10854 |
| Alpha-1,4-glucan-protein synthase (UDP-forming) | 121, 13209, 17615 |
| Alpha-1,6-glucosidases, pullulanase-type | 4515 |
| Alpha-amylase beta-sheet, C-terminal | 399, 16285, 17610, 20418, 20940 |
| Alpha-conotoxin | 5268 |
| Alpha-helical ferredoxin | 1344, 1770, 7583 |
| Alpha-hydroxy acid dehydrogenase, FMN-dependent | 299 |
| Alpha-isopropylmalate/homocitrate synthase | 1304, 9099, 17382 |
| Alpha-L-arabinofuranosidase, C-terminal | 1074, 8595 |
| Alpha-N-acetylglucosaminidase | 1598, 9650, 12405, 14513 |
| Alpha/beta hydrolase | 194, 250, 382, 1173, 2703, 2806, 3017, 3051, 3077, 3830, 4109, 6790, 6926, 8711, 10312, 11546 |
| Alpha/beta hydrolase fold-1 | 194, 250, 382, 432, 822, 885, 1173, 1655, 2350, 2703, 2806, 2820, 2989, 3017, 3051, 3061, 3077, 3175, 3391, 3830, 4109, 4320, 5521, 6619, 6790, 6926, 8376, 8711, 8713, 9122, 10107, 10217, 10227, 10305, 10312, 10636, 11050, 11060, 11313, 11546, 11953, 12125, 13894, 14954, 17347, 18297, 19008, 19920 |
| Alpha/beta hydrolase fold-3 | 373, 796, 2119, 2193, 2367, 5623, 6864, 7660, 7832, 8426, 8658, 9334, 9736, 10216, 10958, 16851, 17704 |
| Alpha/gamma adaptin, C-terminal | 1046, 2155, 8757 |
| Alternative oxidase | 1138, 3252, 11100, 12952, 13658, 21770 |
| Aluminium resistance | 12306 |
| Amidase | 1030, 1379, 3303, 3476, 4516, 7141, 8104, 8637, 8835, 9147, 10038, 10224, 15017, 20527 |
| Amidase, hydantoinase/carbamoylase | 1900 |
| Amidohydrolase 1 | 2477, 2576, 3006, 4410, 5445, 11405, 12178, 13377, 19620 |
| Amidohydrolase 2 | 2044, 3587, 9789, 9876 |
| Amidophosphoribosyl transferase | 1764, 14859 |
| Amine oxidase | 549, 1255, 1756, 1875, 2173, 2388, 2716, 2840, 3043, 3290, 4890, 9259, 9427, 9805, 10682, 11441, 11601, 11998, 12731, 13160, 13185, 14066, 14715, 16163, 19205, 21781, 22049 |
| Amino acid permease | 1490, 18423 |
| Amino acid permease-associated region | 371, 1177, 1490, | |