| Molecular Function | Unipeptide Families |
| 3'-5' exonuclease activity | 2286, 3457, 4304, 4405, 4466, 4846, 5392, 6597, 6674, 7148, 8214, 9165, 9769, 14793 |
| 3'-5'-exoribonuclease activity | 3456, 3613, 3990, 4135, 4402, 4420, 4474, 10774, 15949, 16151, 19725 |
| 3-isopropylmalate dehydratase activity | 2821 |
| 3-oxoacyl-[acyl-carrier protein] reductase activity | 1641 |
| 5'-3' exonuclease activity | 3035, 6817, 10478, 19671 |
| 5-amino-6-(5-phosphoribosylamino)uracil reductase activity | 5440 |
| acetate-CoA ligase activity | 1139 |
| acetyltransferase activity | 6127, 12890, 15498 |
| acid phosphatase activity | 323, 834, 1278, 11243, 20130 |
| acyl-CoA oxidase activity | 2926 |
| adenyl-nucleotide exchange factor activity | 2567, 2812, 14434, 19577 |
| alpha-N-arabinofuranosidase activity | 1074, 8595 |
| aminoacylase activity | 955, 13083 |
| AMP binding | 1139 |
| anion exchanger activity | 1220, 8179 |
| aspartate carbamoyltransferase activity | 3718 |
| aspartate kinase activity | 1890 |
| aspartate-semialdehyde dehydrogenase activity | 3370 |
| ATP binding | 71, 112, 139, 181, 187, 203, 209, 228, 335, 400, 438, 524, 582, 649, 741, 758, 771, 798, 872, 892, 895, 958, 1147, 1170, 1239, 1276, 1376, 1394, 1446, 1501, 1554, 1567, 1620, 1621, 1868, 1889, 1942, 1990, 2053, 2196, 2214, 2272, 2320, 2646, 2650, 2814, 2822, 3084, 3201, 3240, 3385, 3487, 4211, 5080, 5419, 5424, 5473, 5580, 5697, 5738, 5801, 6246, 6342, 6920, 7284, 7512, 7538, 7567, 7790, 7808, 7959, 7967, 7968, 7981, 7986, 7987, 8002, 8143, 8527, 8842, 8872, 8881, 9047, 9102, 9330, 9339, 9448, 9467, 9723, 10030, 10085, 10156, 10228, 10661, 11132, 11426, 11573, 11605, 11886, 12051, 12492, 12626, 12701, 13075, 13158, 13317, 13872, 13884, 13889, 13962, 13975, 14017, 14072, 14146, 14528, 14579, 14701, 14755, 14962, 15012, 15032, 15272, 15289, 15664, 15811, 15854, 15986, 16130, 16157, 16226, 16364, 16661, 16787, 17028, 17209, 17345, 17448, 18081, 18144, 18329, 18332, 18526, 18983, 19013, 19151, 19158, 19415, 19442, 19499, 19954, 19956, 20008, 20031, 20033, 20213, 20327, 20533, 20555, 20841, 20978, 20980, 21012, 21091 |
| ATP-dependent DNA helicase activity | 5419, 10156 |
| ATP-dependent helicase activity | 649, 7567, 7808, 9102, 12051, 13075, 13158, 15012, 18081, 18332 |
| ATPase activity | 82, 85, 106, 126, 206, 307, 396, 476, 652, 1073, 1090, 1135, 1163, 1484, 1930, 1958, 2209, 2303, 2646, 2653, 3084, 3312, 3487, 3505, 3519, 3636, 4002, 4817, 4968, 4971, 5055, 5390, 5857, 6246, 6732, 7136, 7966, 9964, 10416, 10835, 13228, 13511, 14072, 14103, 16155, 20032 |
| beta-lactamase activity | 2876, 17817, 21856 |
| binding | 17, 32, 265, 267, 421, 430, 794, 1006, 1086, 1341, 1345, 1489, 1903, 2960, 3526, 3683, 3944, 4367, 5071, 5506, 7212, 9028, 11490, 13141, 14338, 14818, 15963, 19084, 21453, 22112 |
| biotin binding | 2196, 2650, 9467, 16130, 20033 |
| biotin synthase activity | 2510, 19964 |
| calcium ion binding | 406, 642, 1230, 2291, 4619, 5477, 5540, 6293, 6305, 7724, 10382, 12151, 13520, 14014, 15673, 20577 |
| carboxy-lyase activity | 460, 942 |
| caspase activity | 1069, 1199 |
| catalase activity | 73, 19934 |
| catalytic activity | 63, 155, 196, 460, 620, 726, 740, 1024, 1236, 1296, 1378, 1437, 1502, 1512, 1669, 1697, 1781, 1783, 2048, 2133, 2196, 2510, 2575, 2650, 2762, 2799, 2841, 3886, 3964, 4084, 4113, 4279, 4384, 4552, 4567, 4794, 5068, 5421, 6976, 8462, 8695, 9356, 10181, 10452, 10860, 10921, 11231, 11725, 11788, 12163, 12309, 13019, 14433, 14468, 14615, 15016, 16459, 17449, 19599, 19912 |
| chitinase activity | 2296, 4657 |
| chlorophyll binding | 4388, 5114, 10471, 14762, 15593 |
| chlorophyllase activity | 2836 |
| copper ion binding | 87, 94, 623, 1579, 2062, 3516, 9913, 16070, 16181, 17074, 19045, 21729 |
| coproporphyrinogen oxidase activity | 14468 |
| cyclin-dependent protein kinase regulator activity | 2856, 17732 |
| cytochrome-b5 reductase activity | 723 |
| cytochrome-c oxidase activity | 3516, 16070 |
| D-alanine-D-alanine ligase activity | 9557 |
| damaged DNA binding | 14664 |
| dihydroorotate oxidase activity | 2559 |
| DNA binding | 53, 207, 221, 330, 663, 882, 911, 1060, 1065, 1169, 1552, 1692, 1728, 2121, 2272, 2547, 2632, 3198, 3410, 4049, 5119, 5329, 5344, 5419, 5872, 6028, 6173, 6196, 6223, 6460, 6550, 6804, 6860, 6874, 7119, 7482, 7807, 8045, 8213, 8601, 8953, 9166, 9213, 9330, 9500, 9554, 9616, 10156, 10233, 10735, 11016, 11679, 11910, 11951, 12327, 12353, 12424, 12775, 12870, 13219, 13498, 13836, 15029, 15137, 15731, 15812, 16067, 16161, 16390, 17019, 17782, 17840, 17886, 17957, 18160, 18703, 19036, 19306, 19368, 19537, 19663, 19689, 20017, 20205, 20506, 20595, 20876, 20947, 20952, 21731, 22026 |
| DNA helicase IV activity | 958, 19415 |
| DNA ligase (ATP) activity | 2272, 11886, 12814 |
| DNA topoisomerase (ATP-hydrolyzing) activity | 9330 |
| DNA-directed RNA polymerase activity | 2405, 2523, 2871, 2956, 4193, 5119, 5872, 5958, 9216, 14813, 15812, 17390, 17960, 18380, 20535 |
| dopamine beta-monooxygenase activity | 2829, 7491 |
| electron carrier activity | 540 |
| electron transporter activity | 303, 491, 976, 3170, 3322, 5955, 6010, 7437, 10459 |
| FAD binding | 452, 577, 718, 723, 936, 1140, 1808, 2926, 3965, 19702 |
| ferredoxin-NADP+ reductase activity | 452 |
| ferrous iron binding | 1536 |
| FMN binding | 299, 426, 674, 785, 2500, 3548, 3767, 3964, 4643, 6995, 7809, 9191, 11954, 13934, 19120, 19135, 19502 |
| geranylgeranyl reductase activity | 1253 |
| glucose-1-phosphate adenylyltransferase activity | 316 |
| glutamate decarboxylase activity | 317 |
| glutamate-cysteine ligase activity | 1947 |
| glutamyl-tRNA(Gln) amidotransferase activity | 5266 |
| growth factor activity | 9850, 13366, 18828, 20103 |
| GTP binding | 3490, 4942, 10142, 10843, 10865, 17932, 21078 |
| GTPase activity | 1082, 1160, 1191, 4942, 9813, 11786, 14869, 15585, 15586, 17932, 21078 |
| GTPase binding | 3490, 10843, 10865 |
| guanyl nucleotide binding | 12, 1017, 2771 |
| guanyl-nucleotide exchange factor activity | 3490, 10843, 10865 |
| helicase activity | 112, 139, 181, 187, 649, 758, 872, 892, 895, 1147, 1376, 1446, 1501, 1868, 1889, 1990, 3201, 3385, 4211, 5424, 5473, 5580, 5697, 5738, 5801, 6342, 6920, 7512, 7790, 8872, 8881, 9047, 9339, 9448, 10156, 10228, 10661, 12626, 13889, 13962, 13975, 14017, 14701, 15032, 15272, 15811, 15986, 16364, 17028, 18983, 19013, 21012, 21091 |
| heme binding | 17, 44, 64, 238, 239, 332, 359, 362, 387, 425, 519, 525, 579, 953, 976, 1076, 1151, 1235, 1245, 1281, 1308, 1521, 1667, 1804, 2077, 2172, 2344, 2697, 3414, 3450, 3520, 3898, 4546, 6010, 6311, 6629, 6641, 7061, 7267, 7961, 7970, 7977, 7980, 7985, 8030, 9498, 11038, 11821, 12721, 12722, 12993, 13189, 13250, 13327, 13522, 13569, 14509, 14570, 14941, 15064, 15129, 15186, 15303, 15560, 15639, 15953, 15991, 16174, 16177, 16307, 16314, 16340, 16375, 16474, 16599, 16870, 17021, 17120, 17122, 17607, 17753, 18021, 18151, 18290, 18769, 18886, 19167, 19218, 20191, 20235, 21766, 21787, 21849, 21921, 21966 |
| histidinol dehydrogenase activity | 2340 |
| hydro-lyase activity | 3390 |
| hydrolase activity | 405, 1900, 2365, 3825 |
| hydroxymethylglutaryl-CoA synthase activity | 1014 |
| inorganic diphosphatase activity | 193, 386, 437, 490, 680, 1069, 1210, 2194, 3048, 3700, 7029, 9450, 13920, 14484, 14904, 15721, 15904 |
| inositol or phosphatidylinositol phosphatase activity | 8743 |
| iron ion binding | 17, 44, 64, 238, 239, 303, 332, 362, 519, 525, 579, 654, 785, 953, 1076, 1087, 1235, 1245, 1278, 1281, 1296, 1308, 1344, 1521, 1667, 2077, 2172, 2344, 2510, 2697, 2799, 2864, 3414, 3450, 3520, 3797, 3886, 3898, 3964, 4183, 4279, 4546, 4567, 5068, 5086, 5192, 5421, 5819, 5955, 6010, 6629, 6641, 7267, 7961, 7970, 7977, 7980, 7985, 8345, 9336, 9498, 10181, 10921, 11038, 11821, 12721, 12722, 12993, 13189, 13250, 13327, 13569, 14433, 14468, 14509, 14570, 14941, 15064, 15129, 15186, 15303, 15560, 15639, 15953, 15991, 16174, 16177, 16307, 16314, 16340, 16375, 16403, 16474, 16599, 16870, 17021, 17120, 17122, 17371, 17607, 17753, 18021, 18151, 18290, 18769, 18886, 19167, 19218, 19841, 19964, 20191, 20235, 21766, 21787, 21849, 21921, 21966 |
| iron ion transporter activity | 5220 |
| isocitrate dehydrogenase (NADP+) activity | 502 |
| isopentenyl-diphosphate delta-isomerase activity | 1451 |
| L-lactate dehydrogenase activity | 2168 |
| L-malate dehydrogenase activity | 169, 656, 9725, 14025, 14058, 15193 |
| ligase activity | 1206, 2196, 2360, 2650, 4962, 6209, 9394, 9467, 16130, 20033, 20944 |
| lipase activity | 120, 127, 161 |
| lipid transporter activity | 7890, 17624 |
| lyase activity | 1637 |
| magnesium ion binding | 209, 386, 437, 460, 490, 680, 1069, 1210, 2194, 3048, 3700, 7029, 7284, 9450, 13920, 14484, 14664, 15904 |
| magnesium protoporphyrin IX methyltransferase activity | 17713 |
| malate dehydrogenase activity | 656 |
| manganese ion binding | 775, 1804 |
| mannosidase activity | 613, 3131, 11763, 12213, 18308 |
| metal ion binding | 502, 654, 2763, 16449, 21019 |
| metalloendopeptidase activity | 228, 400, 11605, 15854 |
| methylmalonate-semialdehyde dehydrogenase (acylating) activity | 1347 |
| microtubule motor activity | 621, 1021, 1129, 1468, 8218, 13468, 14219, 14886, 15707, 15988, 17394, 18748, 18938, 19430, 20954 |
| monooxygenase activity | 17, 44, 64, 238, 239, 332, 362, 519, 525, 579, 953, 1076, 1235, 1245, 1308, 1521, 1667, 2077, 2172, 2344, 2697, 3414, 3450, 3520, 3898, 4546, 6629, 6641, 7267, 7961, 7970, 7977, 7980, 7985, 9498, 11038, 11821, 12721, 12722, 12993, 13189, 13250, 13327, 13569, 14509, 14570, 14941, 15064, 15129, 15186, 15303, 15560, 15639, 15953, 15991, 16174, 16177, 16307, 16314, 16340, 16375, 16474, 16599, 16870, 17021, 17120, 17122, 17607, 17753, 18021, 18151, 18290, 18769, 18886, 19167, 19218, 20191, 20235, 21766, 21787, 21849, 21921, 21966 |
| motor activity | 5091, 20149, 20429 |
| N-acetyl-gamma-glutamyl-phosphate reductase activity | 3346 |
| NAD+ ADP-ribosyltransferase activity | 789, 2257, 5953, 14998, 20692 |
| NADH dehydrogenase (ubiquinone) activity | 5450 |
| NADP binding | 452, 2187, 3370, 5440 |
| nickel ion binding | 3006, 3360 |
| nucleic acid binding | 24, 36, 112, 124, 139, 173, 181, 187, 213, 253, 256, 501, 622, 649, 682, 691, 727, 758, 774, 807, 811, 855, 872, 888, 892, 895, 917, 978, 994, 1027, 1058, 1075, 1093, 1101, 1131, 1147, 1164, 1178, 1195, 1261, 1321, 1365, 1371, 1376, 1380, 1446, 1448, 1501, 1519, 1582, 1767, 1777, 1850, 1868, 1889, 1990, 2115, 2222, 2486, 2532, 2578, 2608, 3113, 3155, 3199, 3201, 3244, 3329, 3341, 3385, 3481, 3992, 4130, 4211, 4309, 4401, 4429, 4617, 4799, 4887, 4906, 4963, 5022, 5155, 5235, 5424, 5473, 5481, 5495, 5580, 5651, 5697, 5738, 5801, 5964, 5977, 6175, 6294, 6295, 6342, 6388, 6487, 6583, 6663, 6721, 6737, 6841, 6920, 6930, 7011, 7066, 7193, 7406, 7419, 7509, 7512, 7534, 7565, 7580, 7592, 7681, 7696, 7780, 7790, 8101, 8197, 8205, 8424, 8472, 8634, 8864, 8872, 8881, 9047, 9185, 9339, 9369, 9448, 9454, 9514, 9682, 9733, 9770, 10033, 10156, 10228, 10307, 10308, 10392, 10661, 10685, 10726, 10746, 10816, 10902, 10914, 11081, 11376, 11642, 11695, 11770, 11920, 11975, 12025, 12134, 12245, 12474, 12504, 12547, 12626, 12674, 12930, 13039, 13280, 13574, 13578, 13581, 13644, 13854, 13889, 13899, 13962, 13975, 14017, | |